Penilaian Proses Kapabilitas PT XYZ Menggunakan Framework COBIT 5

Penilaian kapabilitas dilakukan untuk mengetahui kapabilitas PT Fiture Teknologi Inovasi dan memberikan rekomendasi perbaikan untuk perkembangan perusahaan kedepanya. Framework COBIT 5 dipilih karena dapat disesuaiakan dengan kebutuhan perusahaan dan setara dengan framework berskala internasional lainya. Penilaian kapabilitas menggunakan 3 domain yaitu APO08 Manage relationship, APO12 Risk management dan BAI02 Manage Requirements Definition. Ketiga domain ini dipilih dengan metode cascade goals COBIT 5 berdasarkan tujuan, visi dan misi PT Fiture Teknologi Inovasi. Target kapabilitas perusahaan ada pada level 3 estabilised. Hasil penilaian kapabilitas pada domain APO08 dan APO12 pada level 1 (perfomed) adalah fully achieved dan pada level 2 (managed) adalah largely achieved. Hasil domain BAI02 pada level 1 adalah largely achiveved. Hasil penilaian dijadikan acuan untuk memberikan rekomendasi untuk membuat key performance indicator, mengupdate memorandum of understanding dan membenahi humman resource

Ascl3 marks adult progenitor cells of the mouse salivary gland

AbstractThe Ascl3 transcription factor marks a subset of salivary gland duct cells present in the three major salivary glands of the mouse. In vivo, these cells generate both duct and secretory acinar cell descendants. Here, we have analyzed whether Ascl3-expressing cells retain this multipotent lineage potential in adult glands. Cells isolated from mouse salivary glands were cultured in vitro as non-adherent spheres. Lineage tracing of the Ascl3-expressing cells within the spheres demonstrates that Ascl3+ cells isolated from adult glands remain multipotent, generating both duct and acinar cell types in vitro. Furthermore, we demonstrate that the progenitor cells characterized by Keratin 5 expression are an independent population from Ascl3+ progenitor cells. We conclude that the Ascl3+ cells are intermediate lineage-restricted progenitor cells of the adult salivary glands

The Treatment of Morton’s Neuroma, a Significant Cause of Metatarsalgia for People Who Exercise

Morton’s Neuroma is a common metatarsalgia in athletes created due to the entrapment of the inter-digital nerve inside the transverse inter-metatarsal ligament. The purpose of the present study is to draw the necessary conclusions from the use of a particular surgical treatment to release the digital nerve, accompanied by neurolysis in adults who exercise. On the whole, twenty five patients with twenty-five suffering extremities were treated. Five of them simultaneously had a Hallux Valgus type deformity and that supports the belief of the mechanical induce of this condition. Both ultrasonography and Magnetic Resonance Imaging (MRI) were used for the clinical evaluation of this condition. The pain was estimated via the Visual Analogue Scale (VAS). The patients were re-examined after three (1st postoperative), twelve (2nd postoperative) and twenty-four (3rd postoperative) months. A significant improvement (p < 0.0001) was noticed from the correlation between the pain before the surgery and the pain after the surgery via the Visual Analogue Scale (VAS). Most patients (15/25) did not display any discomfort or sensory disorder after surgery. The correct clinical evaluation as well as the correct and effective surgical intervention with the simultaneous repair of all the mechanical deformities of the foot provided better post-surgery progress in patients and increased the percentage of their rehabilitation of their previous activities

Percutaneous Surgical Technique for Persistent Tennis Elbow: A Comparative Study

“Tennis Elbow” or Lateral Epicondylitis is a painful syndrome of the elbow which affects a large portion of the adult population, such as heavy labour workers and athletes. The aim of this comparative study is the investigation of the results of the percutaneous technique as a surgical treatment method compared to the conservative treatment for people suffering from this syndrome. Fourty-six patients with 52 suffering elbows constituted the group that was treated surgically and 51 patients with 59 suffering elbows constituted the group that was treated conservatively. The Verhaar et al. scoring system was used for the evaluation of the treatment results both preoperatively or before the beginning of the conservative treatment and 15 days and one, two, four and six months postoperatively. The Verhaar et al. scoring system was also used for the evaluation of the pain, the local sensitivity, the hand grip with the use of a dynamometer and the elbow’s and forearm’s range of motion (ROM) with the use of a goniometer. It has been demonstrated that the percutaneous technique is superior to the conservative treatment because it provides better results. In addition, the patients who were treated with the percutaneous technique developed a greater range of motion (ROM) in the elbow extension, the supination and mainly in the pronation of the forearm in the reevaluations compared to the conservatively treated group. In conclusion, the percutaneous release of the extensor tendons in the elbow, in cases of the “Tennis Elbow” syndrome, provides very good results. At the same time it is an easier and safer procedure compared to other surgical techniques

Minimal pre-mRNA substrates with natural and converted sites for full-round U insertion and U deletion RNA editing in trypanosomes

Trypanosome RNA editing by uridylate insertion or deletion cycles is a mitochondrial mRNA maturation process catalyzed by multisubunit complexes. A full-round of editing entails three consecutive steps directed by partially complementary guide RNAs: pre-mRNA cleavage, U addition or removal, and ligation. The structural and functional composition of editing complexes is intensively studied, but their molecular interactions in and around editing sites are not completely understood. In this study, we performed a systematic analysis of distal RNA requirements for full-round insertion and deletion by purified editosomes. We define minimal substrates for efficient editing of A6 and CYb model transcripts, and established a new substrate, RPS12. Important differences were observed in the composition of substrates for insertion and deletion. Furthermore, we also showed for the first time that natural sites can be artificially converted in both directions: from deletion to insertion or from insertion to deletion. Our site conversions enabled a direct comparison of the two editing kinds at common sites during substrate minimization and demonstrate that all basic determinants directing the editosome to carry out full-round insertion or deletion reside within each editing site. Surprisingly, we were able to engineer a deletion site into CYb, which exclusively undergoes insertion in nature

The efficacy of antibiotics to prevent collibacilosis in broiler poultry: A protocol for a systematic review and network meta-analysis.

Antibiotics are used in broiler poultry production both for the prevention and treatment of infectious diseases. However, antibiotic use is a driver of antibiotic resistance. The World Health Organization has published numerous reports urging all stakeholders concerned with both food-producing animals and humans to establish recommended steps to enhance the prudent use of antimicrobials (WHO, 2015). Similarly, the World Animal Health Organization has also published recommendations and position statements regarding prudent use and risk management related to antimicrobial use in animals (OIE, 2017). Colibacillosis is an important bacterial pathogen of poultry, and a costly disease for the industry resulting in multimillion dollar losses annually through morbidity, mortality or carcass condemnation at slaughter. Colibacillosis refers to any localized or systemic infection caused entirely or partly by the organism avian pathogenic Escherichia coli (APEC). These bacteria may be isolated as the sole pathogen or contribute to a disease complex with mixed viral and bacterial infections (Guabirara and Schouler, 2015). Two main disease processes important in the broiler industry are early mortality and cellulitis. Early mortality is defined by chicks under a week of age experiencing a higher than normal percentage of deaths in a flock. Early mortality can be caused by many things, for example chilling, overheating, or dehydration, however E.coli infection, or colibacillosis, is one of the main culprits. Colibacillosis can present with omphalitis, yolk sacculitis, enteritis, pasty vents, pericarditis, perihepatitis, polyserositis, congested lungs, splenomegaly and darkened proventriculus or any these combinations (Guabiraba and Schouler, 2015; Geetha and Palanivel, 2018). Many chicks succumb to an early and severe infection or are culled due to excessive morbidity. Antibiotics are typically used to reduce early mortality (Chauvin et al., 2005; Dziva and Stevens, 2008). Those with severe infection are unlikely to survive, however appropriate treatment reduces transmission between birds and improves the suitability of those with a mild infection. Not every labelled drug for E.coli is efficacious, resistance is common (Kabir, 2010) and effectiveness can vary from flock to flock, even within a flock, with more than one strain and more than one treatment. Understanding the efficacy of antibiotics used to prevent colibacillosis in broiler chickens is essential to optimizing their use; ineffective antibiotics should not be used for prevention or, if there are multiple efficacious antibiotics, their importance to human medicine should be considered when making decisions on antibiotic use. Systematic reviews of randomized controlled trials, and network meta-analysis to provide input on relative antibiotic efficacy, will yield the highest level of evidence for efficacy of treatments under field conditions (Sargeant and O’Connor, 2014)

Creating Overall Measurements of Unidimensional Constructs for Comparative Research: A Methodological Study

This article was added to the Knowledge Bank in January, 2023.Standardization of measurement is a prerequisite for cross-national and/or overtime comparative analyses. However, there are instances in the literature where the validation of constructs resulted in producing scales or subscales defined differently from the proposed theoretical structure and across countries. In this paper, we propose an empirical methodology that provides standardized overall measurements of unidimensional constructs to be used in cross-national and overtime comparative research. Initially, the inclusion of items for further analyses is investigated at country level and overtime. The common items are to define the overall measurements and their structure is validated. Based on the Confirmatory factor analyses results, their psychometric properties are assessed. To demonstrate the implementation of the suggested methodology and facilitate practical applications, we use the human values measurements included in the European Social Survey questionnaire for Southern Europe, 2002-2018. Moreover, in order to show how these measurements may be used in further analyses, their association to subjective life satisfaction, happiness and general health are also presented

Image Error Detection: A Systematic Literature Review

The advancement of technology, as well as the creation of new techniques and methodologies for image analysis, is rapid. However, image detection may face some errors. Image error detection will be discussed in this comprehensive literature review. Throughout the papers, this work attempts to learn about the types of images used, algorithms that are frequently used, techniques that are frequently used, and metrics used to test the correctness of the suggested approach. The most commonly used image type is medical images such as Magnetic Resonance Imaging, the algorithm that is widely used is a Convolutional Neural Networks based algorithm. The method that is widely used is a machine learning-based method, and the measurement that is widely used is a Peak Signal Noise Ratio measurement method to measure the accuracy of the algorithm

Radiative Decay Rate and Branching Fractions of MgF

We report measured and calculated values of radiative decay rates and vibrational branching fractions for the A$^2\Pi$ state of MgF. The decay rate measurements use time-correlated single photon counting with roughly 1% total uncertainty. Branching-fraction measurements are performed using two calibrated imaging systems to achieve few percent total uncertainty. We use the highly accurate multireference relativistic ab initio methods to calculate the Franck-Condon factors and transition dipole moments required to determine the decay rates and the branching fractions. The measurements provide a precision benchmark for testing the accuracy of the molecular structure calculations. The determination of the decay rate and vibrational branching fractions can be used to inform future optical cycling and laser cooling schemes for the MgF molecule